Treatment of primary first-episode genital herpes simplex virus infections with acyclovir: results of topical, intravenous and oral therapy. Corey L, Benedetti J, Critchlow C, Mertz G, Douglas J, Fife K, Fahnlander A, Remington ML, Winter C, Dragavon J. Herpes simplex virus infection is increasingly common in the United States. Acyclovir therapy remains an effective and often less expensive option. Famciclovir and valacyclovir offer improved oral bioavailability and convenient oral dosing schedules but are more expensive than acyclovir. Effect of Acyclovir (Zovirax) Treatment on Primary Genital Herpes. Double-blind placebo-controlled trial of oral acyclovir in first-episode genital herpes simplex virus infection. This cross reaction can cause problems in interpreting results from CFTs and other tests. A. Primary Infection;- Man is the only natural host to HSV, the virus is spread by contact, the usual site for the implantation is skin or mucous membrane. Initial or first episode – this refers to infection ( clinically apparent or not ) on an anatomical site which has never before been the site for endogenous or exogenous virus. It may be infected by oral or genital lesions from the mother, a herpetic whitlow in a nurse, the father’s eye etc.
Although the treatment approaches used for oral and genital HSV infections are more similar than different, randomized controlled trials (RCT) have uniformly studied these infections separately. In moderate and severe cases, antiviral treatment is often recommended for uncomplicated episodes of primary oral herpes in healthy patients (Table 1). Median duration of oral lesions was 4 days vs 9 days for the placebo group, and median time to negative viral cultures was 1 day vs 5 days. Intermittent episodic therapy with topical acyclovir and penciclovir creams have been shown to decrease lesion healing time and symptomseverity in recurrent labial herpes. Herpes Simplex Virus answers are found in the Johns Hopkins Antibiotic (ABX) Guide powered by Unbound Medicine. Herpetic Eye Disease Study Group has shown that oral acyclovir suppression following initial ocular herpes decreases recurrence by 45 in the 1st year; the greatest suppressive effect may be seen in those with concomitant history of atopy. First clinical episode: if opting for treatment, duration 7-10d.