The Efficacy Of Famciclovir For Initial Episode Genital Herpes Infection Has Not Been Established

The efficacy of famciclovir for initial episode genital herpes infection has not been established 1

The safety and efficacy of famciclovir therapy beyond 1 year of treatment have not been established. The efficacy and safety of Famciclovir tablets have not been established for:. The recommended dosage of Famciclovir tablets for chronic suppressive therapy of recurrent episodes of genital herpes is 250 mg twice daily. Recurrent Orolabial or Genital Herpes in HIV-Infected Patients. Genital herpes simplex is caused by infection with the herpes simplex virus (HSV). In the event that diagnosis and treatment have been based in primary care, arrange follow-up: arrange an appointment at a genitourinary medicine (GUM) clinic in 2 to 3 weeks to allow patient education and a full STI screen. Antiviral therapy reduces the severity and duration of episodes but does not alter the natural history of the disease. Oral aciclovir, valaciclovir, and famciclovir have all been shown to reduce duration (by a median of 1-2 days) and severity of episodes of genital herpes.

The efficacy of famciclovir for initial episode genital herpes infection has not been established 2Immunocompromised patients other than for the treatment of recurrent orolabial or genital herpes in HIV-infected patients. Antiviral therapy for recurrent genital herpes can be administered either as suppressive therapy to reduce the frequency of recurrences or episodically to ameliorate or shorten the duration of lesions. Suppressive therapy reduces the frequency of genital herpes recurrences by 70 80 in patients who have frequent recurrences (345-348); many persons receiving such therapy report having experienced no symptomatic outbreaks. Safety and efficacy have been documented among patients receiving daily therapy with acyclovir for as long as 6 years and with valacyclovir or famciclovir for 1 year (350,351). 6 years and with valacyclovir or famciclovir for 1 year (350,351). It is also indicated for treatment of recurrent episodes of herpes simplex in HIV patients. Use of famciclovir in this manner has been shown to reduce the amount of latent virus in the neural ganglia compared to no treatment or treatment with valaciclovir.

Prevention strategies for sexual and perinatal transmission of HSV have not been well defined. Availability of type-specific serological tests for HSV antibodies may assist in identifying persons at risk for acquiring or transmitting HSV infection. Genital Herpes Infections: Treatment of Recurrent Episodes: Famciclovir was studied in two placebo-controlled trials of 626 otherwise healthy patients with a recurrence of genital herpes who were treated with famciclovir 125 mg b. Animal vectors for human HSV infections have not been described, and humans remain the sole reservoir for transmission to other humans. As compared with recurrent episodes of genital herpes, first episodes of genital herpes infection may have associated systemic symptoms, involve multiple sites including nongenital sites, and have longer lesion duration and viral shedding (49). Isolation of HSV by culture remains the definitive diagnostic method of documenting an HSV infection, including establishing neonatal HSV disease. The safety and efficacy of famciclovir therapy beyond one year of treatment have not been established.

Famvir (famciclovir) Drug Information: Indications, Dosage And How Supplied

For cold sores or genital herpes, take the medication at the first sign of an outbreak or when you feel burning, tingling, or itching. The safety and efficacy of Valtrex in HIV-infected patients has not been established for any treatment other than the suppression of genital herpes. For the treatment of recurrent episodes of genital herpes, Famvir is administered twice daily for 1 day, while Valtrex must be taken for 3 days. Episodic treatment of recurrent genital herpes is of questionable benefit, but it may be helpful in appropriately selected patients. 11 Mechanism and efficacy are similar to those of acyclovir.12 Famciclovir’s intracellular half-life is 10 times longer than acyclovir’s; despite this, dosing less frequently than twice daily is not recommended. Differences in shedding rates between genders have not been identified. Double-blind placebo-controlled trial of oral acyclovir in first-episode genital herpes simplex virus infection. Acyclovir, valacyclovir hydrochloride, and famciclovir are the 3 antiviral drugs routinely used to treat symptomatic herpes simplex virus (HSV) infections. A first episode of genital or oral herpes in a patient already seropositive for HSV is termed a nonprimary initial infection, and these infections tend to be less severe. For instance, famciclovir decreases lesion healing time by 2 days, efficacy that has not been demonstrated with topical therapy. Moreover, the higher dosage was effective in healing established lesions in men, even when initiated after the prodromal period.

New Therapies And Prevention Strategies For Genital Herpes On Jstor