Human herpesvirus-8 (HHV-8) seroprevalence among the general population in the United States is 1 to 5. Rabkin CS, Chibwe G, Muyunda K, Musaba E. Kaposi’s sarcoma in pregnant women. In addition, HHV-8 DNA is found in lymph nodes from AIDS patients with multicentric Castleman disease (MCD),(29) a complex lymphoproliferative disorder characterized by fever, adenopathy, splenomegaly, and elevated levels of human interleukin-6 (IL-6) in the circulation. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS. Jump up Cesarman, E.; Chang, Y.; Moore, P. S.; Said, J. W.; Epidemiological characteristics of human herpesvirus-8 infection in a large population of antenatal women in Zambia.
The first disease associated with HHV-8 infection was KS. However, it soon became appreciated that several other conditions, especially body cavity based lymphoma (also known as primary effusion lymphoma or PEL) and Castleman’s disease, were also linked to this virus. Oksenhendler E, Cazals-Hatem D, Schulz TF, et al. Transient angiolymphoid hyperplasia and Kaposi’s sarcoma after primary infection with human herpesvirus 8 in a patient with human immunodeficiency virus infection. Although human herpesvirus 8 (HHV-8) is the etiologic agent of Kaposi sarcoma (KS), there are no formal guidelines for the clinical management of HHV-8 infection. Both Epstein-Barr virus (EBV) and HHV-8 belong to the gamma-herpesvirus subfamily, and the latter is classified as a human g2-herpesvirus (25). Neyts J, De Clercq E. Antiviral drug susceptibility of human herpesvirus 8.
Of the human herpesviruses, EBV and HHV-8 are in class C. In this grouping, the number of direct terminal repeats are smaller than for other herpesviruses and there are other repeats found within the genome itself that subdivide the genome into unique stretches 2. E. Comparisons of HHV-8 to other herpesviruses. Based on the analysis of the ORF-K1 and ORF-15 genes, five HHV-8 variants (groups A to E) have been identified. Group B is dominant in Africa; D and E are confined to Pacific Island and Amerindian populations. Jeffrey N. Martin, M.D., M.P.H., Donald E. Ganem, M.D., Dennis H. Although human herpesvirus 8 (HHV-8) has been suspected to be the etiologic agent of Kaposi’s sarcoma, little is known about its seroprevalence in the population, its modes of transmission, and its natural history.
Disease Associations Of Human Herpesvirus 8 Infection
Primary HHV-8 infection was associated with mild, nonspecific signs and symptoms of diarrhea, fatigue, localized rash, and lymphadenopathy. E., Conant, M. & Ganem, D. Frequent presence of herpesviral-like DNA sequences in lesions of HIV-negative Kaposi’s sarcoma. Human herpesvirus 8 (HHV-8) or Kaposi’s sarcoma associated herpesvirus (KSHV) is associated with Kaposi’s sarcoma and primary effusion lymphoma. Chemical compound and disease context of Herpesvirus 8, Human. E.G., Gutkind, J.S., Asch, A.S., Cesarman, E., Gershengorn, M.C., Mesri, E.A., Gerhengorn, M. Human Herpes Virus 8 (HHV8) is an oncogenic virus responsible of Kaposi Sarcoma (KS), a multifocal angiogenic tumor. Since human herpesvirus 8 (HHV8; also known as Kaposi Sarcoma Herpesvirus KSHV ) DNA sequences were first identified in cutaneous Kaposi sarcoma (KS) tissue by Chang et al in 1994,1 much has been learned about its role in the pathogenesis of KS and other lymphoproliferative disorders, including multicentric Castleman disease (MCD) and primary effusion lymphoma (PEL).
Human Herpesvirus 8 A Novel Human Pathogen
Although not totally understood, HHV-8 has also been implicated in other diseases including B-cell lymphomas and multicentric Castleman’s disease. Pulmonary manifestations of HHV-8 infection occur almost exclusively in immunocompromised patients, mostly during HIV infection. In: Arvin A, Campadelli-Fiume G, Mocarski E, et al. eds. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. DC sustain a low level of antiviral functionality during HHV-8 infection in vitro. Cesarman, E., Chang, Y., Moore, P. S., Said, J. W., and Knowles, D. M. (1995). To evaluate and compare the role of human herpes virus 8 (HHV-8) viral loads in different compartments of AIDS-related Kaposi’s sarcoma (AIDS-KS) patients real-time polymerase chain reaction (RT-PCR) was used to determine the genome copy number of HHV-8 in plasma, saliva, tissue and peripheral blood mononuclear cells (PBMC) of 49 AIDS-KS patients.
Human herpesvirus-8 (HHV-8) infection is considered the initiating factor in all forms of Kaposi sar.