Recurrent episodes: 200 mg orally every 4 hours (5 times a day) for 5 days Alternatively, the CDC recommends 400 mg orally 3 times a day for 5 days, 800 mg orally twice a day for 5 days, or 800 mg orally 3 times a day for 2 days. HIV-infected patient, genital herpes: 400 to 800 mg orally 2 to 3 times a day The safety and efficacy of daily acyclovir suppressive therapy have been documented among patients treated orally for up to six years. Patients receiving acyclovir should be adequately hydrated to prevent renal toxicity secondary to crystalluria. With the exception of foscarnet and cidofovir, all are nucleoside analogues. Acyclovir triphosphate prevents viral DNA synthesis by inhibiting the viral DNA polymerase. When started within 24 hours of the onset of a genital herpes recurrence, oral acyclovir reduces the duration of viral shedding by approximately two days, time to healing by just over a day, and time to complete resolution of signs and symptoms by approximately a day (Tyring et al. In one study of 400 mg of oral acyclovir administered twice daily for 4 months, clinical recurrences were reduced by more than half, and culture-confirmed recurrences were reduced by more than two-thirds (Rooney et al. 5 mg per pound) of body weight, injected slowly into a vein over at least a one-hour period, and repeated every eight hours for five to ten days.
Medscape – Herpes simplex, zoster-specific dosing for Zovirax (acyclovir), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Genital Herpes. Chronic suppression for recurrence: 400 mg PO q12hr for up to 12 months; alternatively, 200 mg 3-5 times daily. 400 mg every 12 hr. Avoid rapid infusion; infuse over 1 hour at constant rate to prevent renal damage. Maintain adequate hydration. Each VyroHexal 400 tablet contains 400 mg acyclovir. INDICATIONS Treatment of initial and recurrent Herpes simplex infections of the skin and mucous membranes, including initial and recurrent genital herpes simplex virus infections. Recurrences of herpes labialis may be diminished with daily oral acyclovir or valacyclovir. 12. Oral acyclovir, valacyclovir (Valtrex), and famciclovir (Famvir) are effective for the treatment of acute recurrences of herpes labialis. Peak viral DNA load occurred at 48 hours, with no virus detected beyond 96 hours of onset of symptoms.4 Recurrent infections may be precipitated by various stimuli, such as stress, fever, sun exposure, extremes in temperature, ultraviolet radiation, immunosuppression, or trauma. In one RCT, treatment with oral acyclovir (400 mg twice per day) resulted in a 53 percent reduction in the number of clinical recurrences and a 71 percent reduction in virus culture-positive recurrences compared with placebo.
If presentation follows genital HSV recurrence, onset typically 5-7 days later. Syndrome: fever, headache (can be severe), photophobia, meningismus; symptoms reach maximum intensity in a few hours. Recurrent HSV: in patients on long-term suppression, consider stopping after 12 months on therapy to observe if patient is still experiencing frequent relapses. 400mg twice daily on prevention of transmission of HSV-2 genital herpes in HIV-1/HSV-2 discordant couples in Africa. First Clinical Episode of Genital Herpes For Pregnant or Nonpregnant Women. Suppressive Therapy for Recurrent Genital Herpes For Pregnant or Nonpregnant Women. (2002). External genital warts: Diagnosis, treatment, and prevention. For preventing a recurrence of genital herpes: 400 mg every 12 hours for 12 months.
Zovirax (acyclovir) Dosing, Indications, Interactions, Adverse Effects, And More
How men and women can catch genital herpes, symptoms, and what you can do. If appropriate (for example, you are home alone), leave the sores exposed to the air to prevent irritation from knickers or underpants. 6 months my herpes appeared m I took 400 mg and my sore have all gone but my virgina is still itching inside what shud I do? It’s already 10 days my sores r gone but itching is still there help. My girl friend sucked my penis for some time,but i never had sex with her that day,after some few hours i felt some itchy and pains in my penis.could it be that i have contracted the virus. Acyclovir is recommended for the treatment of genital herpes in pregnant women (CDC Workowski 2015). Recurrent infection:. All valaciclovir dosages were significantly more effective than placebo at preventing or delaying recurrences (P. One gram of valaciclovir once daily, 250 mg of valaciclovir twice daily, or 400 mg of acyclovir twice daily were more effective in patients with 10 recurrences per year. Patients who withdrew from the study before 12 months with an unknown recurrence status were counted as having had a recurrence during the study in this analysis.