Antiviral agents can be used to treat disease (a therapeutic strategy), to prevent infection (a prophylactic strategy), or to prevent disease (a preemptive strategy). For the treatment of first episode genital herpes, the dose of oral acyclovir is 200 mg orally five times per day, or 400 mg orally three times per day (Table 64. Acyclovir is licensed in the United States for the treatment of initial episodes and management of recurrent episodes of genital herpes, for the treatment of chickenpox, and for the treatment of acute herpes zoster infections. Similarly, herpes zoster is associated with much greater morbidity in patients with impaired cell-mediated immune responses. Following administration of valacyclovir at a dose of 2 g orally four times daily, plasma acyclovir area-under-the-curve (AUC) values approximate those produced by acyclovir given intravenously at a dose of 10 mg/kg every 8 hours. Studies of patients receiving long-term acyclovir for chronic suppression of genital herpes have revealed no cumulative toxicity (Tyring et al. The varicella-zoster virus is the cause of chickenpox and shingles. Herpes simplex viruses cause cold sores and genital herpes.
Find patient medical information for acyclovir oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. It treats cold sores around the mouth (caused by herpes simplex), shingles (caused by herpes zoster), and chickenpox. This medication is also used to treat outbreaks of genital herpes. Acyclovir is an antiviral drug. DRUG CLASS AND MECHANISM: Acyclovir is an antiviral drug, a synthetic nucleoside analogue, that has inhibitory activity (interferes with viral replication) against the herpes viruses, including herpes simplex 1 and 2 (cold sores and genital herpes), varicella-zoster (shingles and chickenpox), and Epstein-Barr virus (mononucleosis). Aciclovir (ACV), also known as acyclovir, is an antiviral medication. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. Classified as a Category B Drug, 20 the CDC and others have declared that during severe recurrent or first episodes of genital herpes, aciclovir may be used.
Acyclovir is one of the oldest drugs used to treat herpes simplex viruses and remains the first line of treatment for these infections. If you’re taking acyclovir to treat chicken pox or shingles, the drug can reduce the severity of your infection. Genital herpes spreads through sexual activity, and taking acyclovir alone may not be enough to prevent it. A: Acyclovir (Zovirax) is an antiviral medication indicated for the acute treatment of herpes zoster (shingles), the treatment of initial episodes and the management of recurrent episodes of genital herpes and the treatment of chickenpox. Medscape – Herpes simplex, zoster-specific dosing for Zovirax (acyclovir), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Acyclovir is an antiviral drug. It slows the growth and spread of the herpes virus in the body. Acyclovir is used to treat infections caused by herpes viruses, such as genital herpes, cold sores, shingles, and chicken pox. Acyclovir may also be used for purposes not listed in this medication guide. Related Drugs. Herpes Simplex, Mucocutaneous / Immunocompetent Host Valtrex, valacyclovir, Famvir, famciclovir, More.
Herpes zoster (shingles) is a painful rash caused by the same virus that causes chickenpox. After an episode of chickenpox, the virus resides in cells of the nervous system. (HSV); HSV-1 causes cold sores and HSV-2 causes genital herpes. Chronic suppressive therapy: Immunocompetent patient: 400 mg orally twice a day; alternatively, 200 mg orally 3 to 5 times a day may be used HIV-infected patient: 200 mg orally 3 times a day or 400 mg orally 2 times a day HIV-infected patient, genital herpes: 400 to 800 mg orally 2 to 3 times a day The safety and efficacy of daily acyclovir suppressive therapy have been documented among patients treated orally for up to six years. HIV-infected patient, genital herpes: 400 to 800 mg orally 2 to 3 times a day The safety and efficacy of daily acyclovir suppressive therapy have been documented among patients treated orally for up to six years. Therapy should be initiated at the earliest sign of chickenpox, no later than 24 hours after onset of rash. Aciclovir is the most widely prescribed antiviral drug in the world. Herpes zoster is infection that results when varicella-zoster virus reactivates from its latent state in a posterior dorsal root ganglion. Treatment is antiviral drugs given within 72 h after skin lesions appear. Genital Herpes. Genital herpes is an infection caused by the herpes simplex virus (HSV). After an attack of chickenpox, the virus stays in the nerve cells. Shingles is more common in people with immune systems that are weakened from HIV infection, chemotherapy or radiation treatment, transplant operations, or stress. The first antiviral medication used to treat herpes was acyclovir. Herpes simplex virus (HSV) is a DNA virus, belonging to the family Herpesviridae. VZV causes two major syndromes: varicella (chickenpox) and zoster (shingles). Similar to treatment of HSV, antivirals for VZV reduce viral shedding and duration of disease.
This is not the same virus that causes genital herpes. Acyclovir or similar antiviral drugs may be used for children over age 12 and adults who have a high risk for developing complications and severe forms of chickenpox. Exclusive of the antiretroviral agents used in HIV (AIDS) therapy, there are currently only 11 antiviral drugs available, covering four types of virus. Acyclovir (Zovirax), famciclovir (Famvir), and valacyclovir (Valtrex) are effective against herpesvirus, including herpes zoster and herpes genitalis. Shingles An disease caused by an infection with the Herpes zoster virus, the same virus that causes chickenpox. In herpes zoster, antiviral therapy should be given within 72 hours of onset to patients aged over 50 years or with severe pain or neurological abnormalities to reduce the likelihood and duration of postherpetic neuralgia. Oral agents available in Australia for genital herpes comprise the nucleoside analogues aciclovir, valaciclovir and famciclovir. Foscarnet (or vidarabine) is used for aciclovir-resistant HSV in immunocompromised patients. Compare herpes antiviral drugs: differences and similarities of Acyclovir (Zovirax), Valacyclovir (Valtrex) and Famciclovir (Famvir). The major drugs developed to work against herpes simplex virus (HSV) are antiviral agents called nucleosides and nucleotide analogues, which block viral reproduction. The antiviral medications available in pill form acyclovir, valacyclovir, famciclovir have been specifically developed for the treatment of genital herpes.
Acyclovir also can be useful in the treatment or prevention of herpes simplex infections in neonates. A second study6 also found that acyclovir prophylaxis, given in the second week following exposure, allowed seroconversion without the development of symptoms. Two other antiviral agents, famciclovir (Famvir) and valacyclovir (Valtrex), are available for the treatment of herpes zoster and recurrent genital herpes. Acyclovir is an antiviral agent, prescribed for herpes simplex, genital herpes, herpes zoster and chickenpox. It slows down the growth and spread of the herpes virus.