There is also a small risk of transmission from asymptomatic shedding (when the virus reactivates without causing any symptoms). New England Journal of Medicine. 1991;337:189192. 1991;38:109127. L. Frequency of asymptomatic shedding of herpes simplex virus in women with genital herpes. 1991Frenkel, LM, Brown, ZA, Bryson, YJ et al, Pharmacokinetics of acyclovir in the term human pregnancy and neonate. Prober, et al, 1987Prober, CG, Sullender, WM, Yasukawa, LL et al, Low risk of herpes simplex virus infections in neonates exposed to the virus at the time of vaginal delivery to mothers with recurrent genital herpes simplex virus infections. Browse Original Article articles from the New England Journal of Medicine. Neonatal Herpes Simplex Virus Infection in Relation to Asymptomatic Maternal Infection at the Time of Labor. May 2, 1991; Brown Z.A., Benedetti J., Ashley R., et al.
Episodes of asymptomatic genital shedding appear to decrease over time, with reactivation occurring more than twice as often in the first three months after primary first-episode HSV-2 genital infections than in subsequent three-month periods 13. The New England Journal of Medicine. 1991;10(10):729734. Brown ZA, Selke S, Zeh J, et al. New England Journal of Medicine. 1991; 164: 569576. I had my first outbreak of Genital Herpes about 2 years ago, and since then have got fairly regular outbreaks (every few months). This does expose the baby to a very small risk of infection from possible asymptomatic shedding.
New England Journal of Medicine (Impact Factor: 55.87). Professor, Perinatal Medicine, Dept. of Obstetrics and Gynecology. Delivery, Obstetric. Neonatal herpes simplex virus infection in relation to asymptomatic maternal infection at the time of labor. L. A. & Corey, L. May 2 1991 In: New England Journal of Medicine. Genital herpes in pregnancy: Risk factors associated with recurrences and asymptomatic viral shedding. Genital shedding of herpes simplex virus among men. Ashley, R., Krieger, J. N. & Corey, L. Mar 23 2000 In: New England Journal of Medicine. Herpes simplex virus seropositivity and reactivation at delivery among pregnant women infected with human immunodeficiency virus-1. Unrecognized versus asymptomatic HSV infection in HIV+ men.
The Immunologic Basis For Severe Neonatal Herpes Disease And Potential Strategies For Therapeutic Intervention
These asymptomatic individuals are the main source of virus transmission, which occurs mostly during periods of asymptomatic viral shedding 36, 37. Genital HSV-2 shedding at the time of delivery is associated with a relative risk of 300 for virus transmission. 12471252, 1991. Z. A. Brown, A. Wald, R. A. Morrow, S. Selke, J. Zeh, and L. Corey, Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant, The Journal of the American Medical Association, vol. New England journal of medicine Prober, C. G., Heath, C. 2012; 366 (18): 1657-1659 View details for DOI 10. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY Brown, E. L., Morrow, R. We used this test, and the previously developed herpes simplex virus type 2 avidity test, to compare maternal herpes simplex virus-1 and herpes simplex virus-2 antibody avidity in women who transmitted herpes simplex virus to the neonate and women who had herpes simplex virus isolated from genital secretions at delivery but who did not transmit herpes simplex virus to their infants. Infants may acquire these infections in utero, peripartum, or postnatally, resulting in a variety of clinical syndromes, ranging from asymptomatic infection to severe infection,with high mortality rates and significant long-term morbidity. Asymptomatic shedding of HSV is the most common mode of transmission of genital herpes infection. Antiviral therapies are effective in reducing viral shedding during these episodes, but are ineffective as a whole since many outbreaks are asymptomatic or have mild symptoms. Thus, the development of a vaccine for genital herpes is needed to control this disease. Neonatal herpes simplex virus infection in relation to asymptomatic maternal infection at the time of labor. Neonatal HSV-2 occurred in 1 of 4 infants born to mothers seronegative at delivery for both HSV-1 and HSV-2, in 4 of 12 infants exposed to HSV-2 whose mothers had only HSV-1 antibodies at delivery, and in none of the infants born to 31 women who were HSV-2-seropositive. CONCLUSIONS: Of the asymptomatic women who shed HSV in early labor, about a third have recently acquired genital HSV, and their infants are 10 times more likely to have neonatal HSV than those of women with asymptomatic reactivation of HSV.