Prognosis is dependent upon the extent of disease and the efficacy of treatment, with highest rates of morbidity and mortality in disseminated infections, followed by central nervous system infection and the least in SEM infection. Neonatal HSV infections, although being relatively uncommon, are associated with significant morbidity and mortality if unrecognised and specific treatment is delayed. Although rare in the UK, neonatal herpes is a severe condition and carries a high risk of morbidity and mortality. The main concern with maternal HSV infection during pregnancy is the risk of neonatal infection, as this can lead to severe neurological impairment and to death. This is rare, but is more likely in mothers who have disseminated herpes infection. There is a high perinatal mortality (50). In such cases, 30 – 50 of newborns become infected. Although rare, it is a major cause of corneal blindness in the US.
Genital herpes is usually caused by HSV-2, although an increasing number of cases of HSV-1 genital disease are occurring in the United States (126) and around the world (18, 41, 139, 162, 191, 227). The 50 culture-positivity rate corresponds to 106 copies of DNA in the CPR assay (240). Although data on neonatal HSV incidence in very recent years have not been systematically gathered, it is the impression of many experts that the severity of neonatal HSV disease, as manifest by devastating CNS and disseminated infections, has increased over the past 5 years. Viral infections in pregnancy are major causes of maternal and fetal morbidity and mortality. Although both HSV-1 and HSV-2 may cause neonatal herpes, HSV-2 is responsible for 70 of cases.
Fetal death higher with infection in 1st trimester. Generalised non-tender lymphadenopathy is present inover 50 patients. 21. Although disseminated HSV infection is uncommon inpregnancy, the mortality is about 50. HSV-2 is primarily associated with lesions of the anogenital region, although both viruses can infect any area. Infants are far more likely to be infected if their mother’s initial herpes infection occurs during the pregnancy. Mortality rate is 50. Late pregnancy complications are well recognized, and intrauterine infection can result in premature labor, intrauterine growth restriction, still-birth, or neonatal death. Many of the estimates of genital HSV infection likely are underestimates since many patients are completely asymptomatic and do not seek care; less than 10 of individuals who are seropositive for HSV-2 have a history of genital HSV. Although rare, such cases of disseminated infection have maternal mortality rates as high as 50.
Torch Infections In Pregnancy Presentation
Disseminated herpes simplex virus (HSV) in the neonate is associated with significant morbidity and mortality. Although primary HSV infection in pregnancy is uncommon, its diagnosis and adequate treatment are important, as neonatal morbidity from primary HSV in third trimester is as high as 30 50 1, 4, 5, 7. In spite of prematurity, severe disseminated infection and hydrops, the infant survived and was neurologically intact. HSV-2-induced NIHF is extremely rare, particularly in the setting of recurrent maternal infection, and this case is, to our knowledge, the first report of a surviving infant.